Myositis with prominent b cell aggregates may meet classification criteria for sporadic inclusion body myositis

Through an integrated clinico-sero-pathological approach (1 –3), four autoimmune myositis (AIM) entities are currently defined: immune-mediated necrotizing myopathy (IMNM), antisynthetase syndrome myositis (ASSM), sporadic inclusion body myositis (sIBM) and dermatomyositis (DM). Although T cell aggregates on muscle biopsy have long been described as part o f the pathological hallmark of these myositis entities (4), prominent B cell aggregates are uncommon and less well characterized.

Source: Neuromuscular Disorders - December 3, 2022 Category: Neurology Authors: Alain Meyer, Yves Troyanov, Pat Korathanakhun, Oc éane Landon-Cardinal, Valérie Leclair, Hughes Allard-Chamard, Josiane Bourré-Tessier, Jean-Paul Makhzoum, Catherine Isabelle, Sandrine Larue, Francois Grand'Maison, Rami Massie, Matthieu Le Page, Anne-M Source Type: research