Ventilation and tissue oxygenation patterns induced by LABA and LAMA in COPD patients

Conclusions: In our cohort of COPD patients, LABA induced greater proximal bronchodilation than LAMA. Despite the opposite gradient of their documented receptor density, both drugs caused a similar peripheral obstruction relief which resulted in an increased tissue oxygenation after LAMA only. Our data suggest that this could be associated to an improvement in the pulmonary capillary vascularization induced by LAMA.

Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Perez Bogerd, S., Van Muylem, A., Maufroy, E., El.Khloufi, Y., Zengin, S., Faoro, V., Malinovschi, A., Michils, A. Tags: 05.01 - Airway pharmacology and treatment Source Type: research