Silencing MMP7 expression with a lung-targeted RNAi molecule limits fibrosis and preserves pulmonary function in bleomycin-injured rats

Conclusions: Integrin targeting ligand-conjugated siRNAs potently silence MMP7 expression, limit fibrosis and improve lung function in the rat bleomycin model. ARO-MMP7 is a promising new therapeutic candidate for the treatment of IPF.

Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Yuan, T., Nicholas, A., Lakomski, N., Afrazi, M., Hamilton, H., Hegge, J., Hamilton, J., Pei, T., Bush, E. Tags: 12.01 - Idiopathic interstitial pneumonias Source Type: research