Purpura fulminans and spotted fever: A case series from South India

Karthik Gunasekaran, Divyaa Elangovan, Susmitha Perumalla, Kundavaram Paul Prabhakar Abhilash, John Antony Jude PrakashJournal of Global Infectious Diseases 2022 14(4):162-164 Purpura fulminans (PF) is associated with acute infections such as meningococcal, staphylococcal, streptococcal, and rickettsial infections. However, there are only a few reports of association of PF with rickettsial fever from India. In this case series of seven adults with PF, four were definitive cases of spotted fever as the ompA real-time polymerase chain reaction was positive. The other three adults were probable cases of spotted fever, as they were positive by immunoglobulin M enzyme-linked immunosorbent assay, and their fever subsided within 72 h of rickettsia-specific therapy. Three of the seven patients had peripheral gangrene. These patients, despite presenting with severe spotted fever, had a favorable outcome. This is attributed to the high index of suspicion and early treatment supported by diagnostic assays.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research