6. The clinical implications of polyploidy in oligodendrogliomas

Oligodendrogliomas are characterized by IDH mutation and whole-arm chromosome 1p/19q co-deletion. Polysomy chromosomes 1q/19p, detected by FISH, has been associated with earlier tumor recurrence and shorter survival. We retrospectively reviewed 58 oligodendroglioma cases tested at our institution, to assess the genome-wide copy number aberrations (CNAs) and mutational profiling. We compared previously identified high-risk genomic alterations between the polyploid and diploid groups, including mutations of NOTCH1, PIK3CA, PIK3R1, homozygous loss of CDKN2A/B, loss of 14q/15q, and gains of 7p/11p.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research