73. Chromosomal microarray-based genomic profiling of T-cell Large Granular Lymphocyte Leukemia

T-cell large granular lymphocyte (T-LGL) leukemia is a rare lymphoproliferative disorder characterized by infiltration of blood and bone marrow with large granular lymphocytes, splenomegaly, and cytopenias. Most patients with T-LGL leukemia follow an indolent course, with a median survival of over 10 years. However, a subset of T-LGL leukemia cases exhibits more aggressive clinical behavior. Recent identification of recurrent activating STAT3 gene mutations in T-LGL leukemia suggests that sequence alterations play a role in the persistence of clonal T-cell expansions.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research