97. The clinical implications of unbalanced CCND1::IGH rearrangement resulted from the 5 ′IGH deletion in multiple myeloma

Multiple myeloma (MM) is cytogenetically heterogeneous. IGH translocation driving the over expression of the fusion partner gene is considered as a primary genomic event in the pathogenesis of MM. Most IGH fusions in MM are balanced, however, unbalanced IGH fusions are frequent. While the unbalanced translocation resulted from the 3 ′IGH deletion has clinical implications, the 5′IGH deletion is not well studied and often could be interpreted as physiological event due to the IGH locus somatic V-D-J recombination.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Xinyan Lu, Amandeep Kaur, Barina Aqil, Juehua Gao, Madina Sukhanova, Yi-Hua Chen Source Type: research