Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms

BCR-ABL-negative myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by the expansion of at least one myeloid lineage cells caused by acquired somatic mutations [1]. A point mutation of valine to phenylalanine at position 617 (V617F) on Janus kinase 2 (JAK2) is the most common mutation found in MPNs [2-5]. JAK2 normally binds to the intracellular domain of cytokine receptors and transduces signals into cells in response to cytokines.

Source: Experimental Hematology - November 25, 2022 Category: Hematology Authors: Chang Liu, Misa Imai, Yoko Edahiro, Shuichi Mano, Hiraku Takei, Mai Nudejima, Akira Kurose, Soji Morishita, Miki Ando, Satoshi Tsuneda, Marito Araki, Norio Komatsu Source Type: research