Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearanc...

Source: Molecular Neurodegeneration - November 23, 2022 Category: Neurology Authors: Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu and Chia-Chen Liu Tags: Research article Source Type: research