Polypunctosides E-K: seven new steroidal saponins from Polygonatum punctatum Royle ex Kunth and their nitric oxide production inhibitory activities

AbstractPolygonatum punctatum Royle ex Kunth is a high-value medicinal plant found in old natural forests. A phytochemical study on the roots of this plant led to the isolation of seven new steroidal saponins including four furostans (1–4) and three furospirostans (5–7). Their structures were elucidated as (25R)-26-O-(β-d-glucopyranosyl)-furost-5-ene-3β,17α,22α,26-tetraol 3-O- α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4)-β-d-galactopyranoside (1), (25R)-26-O-(β-d-glucopyranosyl)-furost-5-ene-3β,14α,17α,22α,26-pentaol 3-O- α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4)-β-d-galactopyranoside (2), (25R)-26-O-(β-d-glucopyranosyl)-furost-5-ene-22α-methoxy-3β,17α,26-triol 3-O- α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4)-β-d-galactopyranoside (3), (25R)-26-O-(β-d-glucopyranosyl)-furost-5-ene-22α-methoxy-3β,17α,26-triol 3-O-[α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4)]-[acetoxy-(→ 6)]-β-d-galactopyranoside (4), 26-O-(β-d-glucopyranosyl)-14α,17α-dihydroxynuatigenin 3-O- α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4)-β-d-galactopyranoside (5), 26-O-(β-d-glucopyranosyl)-17α-hydroxynuatigenin 3-O- α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4)-β-d-galactopyranoside (6), and 26-O-(β-d-glucopyranosyl)-14α-hydroxynuatigenin 3-O- α-l-arabinopyranosyl-(1  → 2)-β-d-glucopyranosyl-(1  → 4...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research