Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records

Conclusions There was no evidence for a difference in risk between mirtazapine and SSRIs or venlafaxine after accounting for baseline characteristics. The higher risk in the mirtazapine versus the amitriptyline group might reflect residual confounding if amitriptyline is avoided in people considered at risk of self-harm. Clinical implications Addressing baseline risk factors and careful monitoring might improve outcomes for people at risk of serious self-harm.
Source: Evidence-Based Mental Health - Category: Psychiatry & Psychology Authors: Tags: Open access Adult mental health Source Type: research