Co-sensitization to the three non-homologous major cashew allergens Ana o 1, Ana o 2 and Ana o 3 is caused by IgE cross-reactivity

CONCLUSIONS: IgE with high affinity to Ana o 3 that cross-reacts with the other two major non-homologous cashew nut allergens might be responsible for the high allergenic potency of cashew nut. These cross-reactive IgE comprises the major fraction of specific IgE in cashew allergic patients, and might be responsible for cross-reactivity between unrelated tree nuts.PMID:36331131 | DOI:10.18176/jiaci.0867

Source: Journal of Investigational Allergology and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Authors: S Kabasser C Radauer E Eber M E Haber K Hieden P Zieglmayer L E Kost S B Sindher S Chinthrajah S Geiselhart K Hoffmann-Sommergruber K C Nadeau H Breiteneder M Bublin Source Type: research