A nanoporous gold film sensor modified with polypyrrole/CuO nanocomposite for electrochemical determination of piroxicam and tramadole

Environ Res. 2022 Nov 4:114633. doi: 10.1016/j.envres.2022.114633. Online ahead of print.ABSTRACTIn this paper, an electrochemical sensor was developed to determine piroxicam (PX) and tramadole (Tr) based on their enhanced electrochemical responses at the surface of the polypyrrole/CuO nanocomposite-modified nanoporous gold film (NPGF) electrode. The experimental results showed that PX provide an oxidation peak at 0.65 V in pH = 8.0. The DPV results were linearly affiliated on PX concentration within the two closed windows (C1PX = 0.05-30.0 μM, correlation coefficient of 0.9905, and C2PX = 50.0-300.0 μM, correlation coefficient of 0.9927). From voltammetric curves, the detection limit (LOD = 3Sb/m) for PX at a surface of PPY-CuO-NPGF electrode was appeared to be 0.01 μM. Furthermore, the ability of PPY-CuO-NPGF electrode for simultaneous measurement of PX and Tr was investigated. The suggested sensor shows a long-time stability, good repeatability, and rapid response in the mixture media of PX and Tr.PMID:36343714 | DOI:10.1016/j.envres.2022.114633
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research