Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective

The objective of the present narrative review was to find the association between PE and hypoxia-inducible factor 1 (HIF-1) in pregnant women from a new perspective.Recent FindingsHIF-1 is the key transcription factor that regulates cellular responses to hypoxia and low oxygen tension. HIF-1 α is involved in the differentiation and growth of the placenta mainly in the first and second trimesters. During normal gestation, HIF-1α responds to the alterations in oxygen tension, cytokine, and angiogenic factors release. HIF-1α is considered a key biomarker of placental function and vascul arization during pregnancy.SummaryHIF-1 α plays a crucial role in the pathogenesis of PE through activation of anti-angiogenic and inhibition of proangiogenic factors. As well, HIF-1α increases the expression of the p38MAPK and NLRP3 inflammasomes, which promote placental inflammation and dysfunction. HIF-1α acts as a potential link be tween inflammatory signaling pathways and the development of PE.
Source: Current Hypertension Reports - Category: Primary Care Source Type: research