Molecules, Vol. 27, Pages 7646: Radiochemical Feasibility of Mixing of 99mTc-MAA and 90Y-Microspheres with Omnipaque Contrast
Molecules, Vol. 27, Pages 7646: Radiochemical Feasibility of Mixing of 99mTc-MAA and 90Y-Microspheres with Omnipaque Contrast
Molecules doi: 10.3390/molecules27217646
Authors:
Chang-Tong Yang
Pei Ing Ngam
Vanessa Jing Xin Phua
Sidney Wing Kwong Yu
Gogna Apoorva
David Chee Eng Ng
Hian Liang Huang
Yttrium-90 (90Y) microspheres are widely used for the treatment of liver-dominant malignant tumors. They are infused via catheter into the hepatic artery branches supplying the tumor under fluoroscopic guidance based on pre-therapy angiography and Technetium-99m macroaggregated albumin (99mTc-MAA) planning. However, at present, these microspheres are suspended in radiolucent media such as dextrose 5% (D5) solution. In order to monitor the real-time implantation of the microspheres into the tumor, the 90Y microspheres could be suspended in omnipaque contrast for allowing visualization of the correct distribution of the microspheres into the tumor. The radiochemical purity of mixing 90Y-microspheres in various concentrations of omnipaque was investigated. The radiochemical purity and feasibility of mixing 99mTc-MAA with various concentrations of a standard contrast agent were also investigated. Results showed the radiochemical feasibility of mixing 90Y-microspheres with omnipaque is radiochemically acceptable for allowing real-time visualization of radioembolization under fluoroscopy.
Source: Molecules - Category: Chemistry Authors: Chang-Tong Yang Pei Ing Ngam Vanessa Jing Xin Phua Sidney Wing Kwong Yu Gogna Apoorva David Chee Eng Ng Hian Liang Huang Tags: Article Source Type: research
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