An Atypical Case of Idiopathic Purpura Fulminans

We present a case of a 5-year-old boy, heterozygous for factor V Leiden, with no history of recent infections, who presented with PF secondary to acquired protein S deficiency. Despite initial supportive treatment, the patient required surgical fasciotomy and extensive skin grafts. The protein S level normalized 4 months following the presentation. In this context, an autoimmune component with transient anti–protein S antibodies was believed to be involved. This case report highlights the course of idiopathic PF due to noninfectious acquired protein S deficiency.

Source: Journal of Pediatric Hematology Oncology - October 31, 2022 Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research