Long noncoding TSI attenuates aortic valve calcification by suppressing TGF- β1-induced osteoblastic differentiation of valve interstitial cells

Calcific aortic valve disease (CAVD) is an active and cellular-driven fibrocalcific process characterised by differentiation of valve interstitial cells (VICs) towards an osteogenic-like phenotype. A recently identified lncRNA, lncTSI, has been reported to inhibit fibrogenesis through transforming growth factor (TGF)- β/Smad3 pathway. Here, the present study aimed to investigate the role of lncTSI in CAVD.

Source: Metabolism - Clinical and Experimental - October 20, 2022 Category: Biomedical Science Authors: Zongtao Liu, Yixuan Wang, Fayuan Liu, Da Zhu, Yuqi Chen, Wei Yen Yim, Ke Hu, Zhenqi Rao, Xiangbin Pan, Fei Li, Nianguo Dong Source Type: research