Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway

Conclusions: G6PD deficiency predisposes cells to enhanced production of pro-inflammatory cytokine IL-8. Mechanistically, G6PD deficiency up-regulates IL-8 through oxidative stress and NF-κB pathway. The palmitate-induced inflammation in G6PD-deficient HepG2 cells could serve as an in vitro model to study the role of altered redox homeostasis in chronic hepatic inflammation.

http://www.journal-inflammation.com/content/12/1/34

Source: Journal of Inflammation - April 24, 2015 Category: Allergy & Immunology Authors: Hung-Chi YangMei-Ling ChengYi-Syuan HuaYi-Hsuan WuHsin-Ru LinHui-Ya LiuHung-Yao HoDaniel Chiu Source Type: research

More News: Drugs & Pharmacology | G6PD | Study

Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-&#954;B signaling pathway

Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway