Multicenter Study of Drain Fluid Amylase as a Biomarker for the Detection of Anastomotic Leakage After Ileal Pouch Surgery Without a Diverting Ileostomy

This study aimed to assess drain fluid amylase as a biomarker of anastomotic leak after ileal pouch surgery and without a diverting ileostomy. DESIGN: This was a multicenter prospective observational cohort study. SETTINGS: The study was conducted at 4 tertiary hospitals in Queensland, Australia. PATIENTS: This study included elective patients undergoing restorative proctectomy and ileal pouch surgery. INTERVENTIONS: Measurement of rectal tube amylase and drain fluid amylase. MAIN OUTCOME MEASURES: The primary measure was observation of increased drain fluid amylase on the day of anastomotic leak. RESULTS: Fifty-three patients were studied. On the day of anastomotic leak, 4 patients in the anastomotic leak group who experienced an early anastomotic leak recorded a median drain fluid amylase of 21,897 U/L compared with a median drain fluid amylase of 25 U/L for those in the no anastomotic leak group (p
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research