Multicenter Study of Drain Fluid Amylase as a Biomarker for the Detection of Anastomotic Leakage After Ileal Pouch Surgery Without a Diverting Ileostomy
This study aimed to assess drain fluid amylase as a biomarker of anastomotic leak after ileal pouch surgery and without a diverting ileostomy.
DESIGN:
This was a multicenter prospective observational cohort study.
SETTINGS:
The study was conducted at 4 tertiary hospitals in Queensland, Australia.
PATIENTS:
This study included elective patients undergoing restorative proctectomy and ileal pouch surgery.
INTERVENTIONS:
Measurement of rectal tube amylase and drain fluid amylase.
MAIN OUTCOME MEASURES:
The primary measure was observation of increased drain fluid amylase on the day of anastomotic leak.
RESULTS:
Fifty-three patients were studied. On the day of anastomotic leak, 4 patients in the anastomotic leak group who experienced an early anastomotic leak recorded a median drain fluid amylase of 21,897 U/L compared with a median drain fluid amylase of 25 U/L for those in the no anastomotic leak group (p
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research