Decreased mitochondrial function in UVA-irradiated dermal fibroblasts causes the insufficient formation of type I collagen and fibrillin-1 fibers

Decreases of collagen fibers and the disappearance of oxytalan fibers are typical symptoms of photoaged skin. Although a low quality of mitochondria (MT) in photoaged skin cells has been observed, it is unknown whether the decreased quality of MT is responsible for the insufficient formation of dermal fibers.

Source: Journal of Dermatological Science - October 6, 2022 Category: Dermatology Authors: Yushi Katsuyama, Yumiko Yamawaki, Yuki Sato, Sora Muraoka, Masaki Yoshida, Yuri Okano, Hitoshi Masaki Source Type: research