Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction

A large population-based family study, with gene-panel sequencing data, investigated the genetic models that explain the residual breast cancer familial aggregation after considering known susceptibility genes. The results may have implications for strategies to identify new breast cancer-susceptibility genes and improve disease-risk prediction, especially at a young age.

Source: The American Journal of Human Genetics - October 6, 2022 Category: Genetics & Stem Cells Authors: Shuai Li, Robert J. MacInnis, Andrew Lee, Tu Nguyen-Dumont, Leila Dorling, Sara Carvalho, Gillian S. Dite, Mitul Shah, Craig Luccarini, Qin Wang, Roger L. Milne, Mark A. Jenkins, Graham G. Giles, Alison M. Dunning, Paul D.P. Pharoah, Melissa C. Southey, D Tags: Article Source Type: research