Intrauterine exposure to omeprazole increases the risk of teeth morphological anomalies in the offspring of a murine model

In this study, we addressed this gap in a murine model. Pregnant female Swiss mice were exposed to daily doses of 40  mg/kg of omeprazole from the 5th to the 17th day of pregnancy and the effects of such exposure on offspring odontogenesis parameters such as morphological abnormalities, disruptions in the ameloblast and odontoblast layers and the presence of dentin matrix were measured. Omeprazole exposure significantly increased the prevalence (control: 21.6%; treatment: 60%; p  = 0.001) and the risk (posterior mean and 95% credible interval; control: 0.230 [0.129; 0.347]; treatment: 0.593 [0.449; 0.730]) of offspring teeth morphological abnormalities, although there were no statistically significant effects of omeprazole exposure on other parameters of tooth developme nt. These findings suggest that there are potential side-effects to offspring oral health of omeprazole use during pregnancy.
Source: Odontology - Category: Dentistry Source Type: research