Sex-specific effects of chronic antidepressant treatment in middle-aged rats: impact of citalopram on cognition and depressive-like behaviors

Aging and the menopausal transition are each associated with affective disorders such as depression and anxiety, which is often co-morbid with cognitive impairment amongst elderly patients. Of note, women are more vulnerable to both cognitive and affective disorders than men. Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), are commonly prescribed to alleviate symptoms of depression and anxiety. Although the antidepressant effects of SSRIs in adults have been characterized, antidepressant and cognitive effects in the aged population are not well understood, especially regarding potential sex differences in efficacy.
Source: Maturitas - Category: Primary Care Authors: Tags: P42 Source Type: research