Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy

Lipodystrophy syndromes involve selective deficiency of adipose tissue and are categorized as generalized, characterized by near total lack of fat, or partial lipodystrophy, characterized by regional deficiency of fat in the lower extremities and preservation or even excess fat in the face, neck, and/or trunk.1 Partial lipodystrophy can be further classified as familial (most commonly caused by heterozygous mutations in LNMA and PPARG) or acquired (often associated with autoimmune conditions). The diagnosis of lipodystrophy is made clinically, with genetic studies performed to complement the clinical diagnosis.

Source: Journal of Clinical Lipidology - September 21, 2022 Category: Lipidology Authors: Marissa Lightbourne, Megan Startzell, Kimberley D. Bruce, Brianna Brite, Ranganath Muniyappa, Monica Skarulis, Robert Shamburek, Ahmed M. Gharib, Ronald Ouwerkerk, Mary Walter, Robert H. Eckel, Rebecca J. Brown Source Type: research