Oleuropein reduces the oxidative effects of tobacco smoke in rats ’ liver and kidney

In this study, potential protective effects of OLE on tobacco, smoke-exposed rats were evaluated. Eighteen male Sprague Dawley rats were divided into 3 groups: Control, Tobacco smoke, Tobacco smoke  + OLE. The rats in tobacco smoke and tobacco smoke + OLE were exposed to tobacco smoke in a glass chamber for 1 h every other day for 12 weeks. Tobacco smoke + OLE were received 10 mg/kg OLE for the last 4 weeks by oral gavage. After 12 weeks, rats were decapitated; kidney and live r tissues were taken. Malondialdehyde (MDA), glutathione (GSH), NO levels together with catalase (CAT) and arginase activity were measured. MDA levels increased in the liver and kidney, while CAT activity and GSH levels decreased in tobacco smoke group. OLE administration decreased MDA levels while increasing CAT activity and GSH levels. NO levels increased in the liver following tobacco smoke, yet, OLE did not change NO significantly. Furthermore, kidney NO levels increased following tobacco smoke and OLE decreased this level. Tobacco smoke did not change kidney arginase levels while OLE decr eased this activity. Our results showed that OLE could be beneficial in reducing the negative impact of tobacco smoke on both the liver and kidney.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research