[The Lancet Infectious Diseases Commission] Sepsis: a roadmap for future research

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments.

Source: The Lancet Infectious Diseases - April 20, 2015 Category: Infectious Diseases Authors: Jonathan Cohen, Jean-Louis Vincent, Neill K J Adhikari, Flavia R Machado, Derek C Angus, Thierry Calandra, Katia Jaton, Stefano Giulieri, Julie Delaloye, Steven Opal, Kevin Tracey, Tom van der Poll, Eric Pelfrene Tags: The Lancet Infectious Diseases Commission Source Type: research