TGFβ priming promotes TNF-induced bone erosion: a promising new target in RA?

Nature Reviews Rheumatology, Published online: 16 September 2022; doi:10.1038/s41584-022-00843-yNew research shows that TNF can directly induce osteoclastogenesis from transforming growth factor-β (TGFβ)-primed macrophages and that knockout of TGFβ signalling limits TNF-induced arthritic bone erosion in mice, suggesting that TGFβ inhibition could enhance the effect of anti-TNF therapy in rheumatoid arthritis.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research