Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology

This study demonstrates that the HbPGL core hydrophobized with phenyl units at 30 mol % degrees via urethane linkages is optimal in respect of the drug encapsulation efficiency and rheological properties including both self-healable and injectable behavior. This work is important because of a proper selection of a building component for the construction of a therapeutic hydrogel platform dedicated to the intravaginal delivery of hydrophobic drugs.PMID:36073031 | DOI:10.1021/acs.biomac.2c00691

Source: Biomacromolecules - September 8, 2022 Category: Biochemistry Authors: Monika Gosecka Daria Jaworska-Krych Mateusz Gosecki Ewelina Wielgus Monika Marcinkowska Anna Janaszewska Barbara Klajnert-Maculewicz Source Type: research