AcroBATics: how dying brown adipocytes trigger browning

Nature Reviews Endocrinology, Published online: 05 September 2022; doi:10.1038/s41574-022-00743-xThermogenic brown and beige adipocytes have gained much attention as potential therapeutic targets in obesity and related cardiometabolic disease. A recent paper in Nature identifies inosine, released from apoptotic brown adipocytes, as an inducer of thermogenic adipose tissue, thereby uncovering an unexpected and novel mechanism of adipose tissue plasticity.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research