Histone ‐stimulated platelet adhesion to mouse cremaster venules in vivo is dependent on von Willebrand factor

ConclusionsHistone-induced platelet adhesion to microvessels in vivo is vWF-dependent and TLR4-independent. Platelet-derived vWF was not necessary for histone-induced platelet aggregation ex vivo. These data are consistent with the notion that endothelial vWF, rather than platelet vWF, mediates histone-induced platelet adhesion in vivo.

Source: Microcirculation - September 3, 2022 Category: Research Authors: Justin A. Courson, Fong W. Lam, Kimberly W. Langlois, Rolando E. Rumbaut Tags: ORIGINAL ARTICLE Source Type: research