Complementary Nck1/2 Signaling in Podocytes Controls {alpha} Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition

Conclusion
These findings reveal distinct, yet complementary, roles for Nck proteins in regulating podocyte adhesion, controlling GBM composition, and sustaining filtration barrier integrity.

Source: Journal of the American Society of Nephrology : JASN - July 29, 2022 Category: Urology & Nephrology Authors: Martin, C. E., Phippen, N. J., Keyvani Chahi, A., Tilak, M., Banerjee, S. L., Lu, P., New, L. A., Williamson, C. R., Platt, M. J., Simpson, J. A., Krendel, M., Bisson, N., Gingras, A.-C., Jones, N. Tags: Normal Kidney Structure and Function Source Type: research