Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance

CONCLUSIONS: Our findings suggest that an impaired maturation of the immune system, an insufficient response to respiratory pathogens, and an immune response modulated by Th1/Th2 imbalance might play a possible role in triggering SIDS. These findings might in part be explained by chronic stress.IMPACT: Maturation of the cytokine and chemokine network may be impaired in SIDS. An imbalance between Th1- and Th2-related cytokines, which may reflect a state of chronic stress causing a more Th2 shift. An impaired immune maturation, an insufficient response to respiratory pathogens, and an immune response modulated by Th1/Th2 imbalance might play a possible role in SIDS.PMID:35986144 | DOI:10.1038/s41390-022-02203-8

Source: Pediatric Research - August 19, 2022 Category: Pediatrics Authors: Dong Qu Theresa A Engelmann Vanessa Preuss Lars Hagemeier Lena Radomsky Kerstin Beushausen Jana Keil Benedikt Vennemann Christine S Falk Michael Klintschar Source Type: research