Effect of quantitative versus qualitative neuromuscular blockade monitoring on rocuronium consumption in patients undergoing abdominal and gynecological surgery: a retrospective cohort study
This study aims to compare the dosage of the neuromuscular blocking agents (NMBA) rocuronium and the need for reversion by sugammadex between those methods. A retrospective, observational analysis was conducted. In the tactile qualitative-neuromuscular monitoring-group (tactile NMM) (n ā=ā244), muscle contractions were assessed tactilely. In the quantitative neuromuscular monitoring-group (nā=ā295), contractions were accessed using an acceleromyograph. Primary endpoints were dosage of rocuronium per minute operation-time (milligram per kilogram bodyweight per minute (mg/kg BW/min)), count of repeated rocuronium administrations and use of sugammadex. Secondary endpoints were: NMM use before repeated NMBA application or extubation, time to extubation, post-operative oxygen demand. A total of nā=ā539 patients were included. nā=ā244 patients were examined with tac tile NMM and 295 patients by quantitative NMM. Quantitative NMM use resulted in significantly lower rocuronium dosing (tactile NMM: 0.01 (Ā±ā0.007) mg/kgBW/min vs. quantitative NMM: 0.008 (Ā±ā0.006) mg/kgBW/min (pā< ā0.001)). In quantitative NMM use fewer repetitions of rocuronium application were necessary (tactile NMM: 83% (nā=ā202) vs. quantitative NMM: 71% (nā=ā208)pā=ā0.007). Overall, 24% (nā=ā58) in the tactile NMM-group, and 20% (nā=ā60) in the quantitative NMM-group received sugammadex ((pā=ā0.3), OR: 1.21 (0.81ā1.82)). Significantly fewer patients in the quan...
Source: Journal of Clinical Monitoring and Computing - Category: Information Technology Source Type: research