Preexisting anti-PF4 antibodies are not further triggered upon vaccination with SARS-CoV-2 vector vaccines in a cohort of 400 health care workers

Vaccine-induced immune thrombotic thrombocytopenia (VITT) was reported after adenovector-based COVID-19 vaccination with ChAdOx1 and Ad26.COV2 ·S as a rare, but very severe complication [1,2]. Thrombosis/hypercoagulation has been reported also as a common complication of (severe) COVID-19 and is probably multifactorial due to endothelial dysfunction caused either by direct viral infection or by hyperinflammation which also leads to activa tion of platelets and the clotting cascade as well as due to alteration of the blood flow, as explained by the Virchow's triad [3].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research