0.005% hypochlorite reduces serine protease in cultured human keratinocytes: Evidences supporting bleach bath improves atopic dermatitis

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease. Current treatment strategy for AD includes alleviating inflammation, normalizing microbiome, and restoring barrier function. Because epidermal density of Staphylococcus aureus (SA) was reported to positively correlate with the disease severity of AD [1], bleach bath (with 0.005% hypochlorite (HOCl) solution) was originally considered as a beneficial anti-septic therapy for AD patients with skin lesions heavily colonized SA [2].

Source: Journal of Dermatological Science - August 8, 2022 Category: Dermatology Authors: Shu-Mei Huang, Yang-Yi Chen, Yin-Chun Chen, Ching-Shuang Wu, Cheng-Che E. Lan Source Type: research