Treat psoriasis with traditional and novel topical therapies

AbstractThe mainstay topical treatments for psoriasis are corticosteroids and/or vitamin D analogues, with retinoids, calcineurin inhibitors, salicylic acid and other agents used for decades. These agents target abnormal cytokine activity and keratinocyte proliferation and differentiation. New research areas include intracellular signalling pathways, with tapinarof being the first aryl hydrocarbon receptor (AhR) modulator to gain approval. Other promising topical agents include additional AhR modulators, phosphodiesterase type 4 inhibitors and janus kinase pathway inhibitors.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research