Correlation between blood ketones and exhaled acetone measured with a semiconducting gas sensor
Breath acetone (BrAce) has been reported to be useful for monitoring the pathophysiology of patients
with diabetes. However, devices that measure BrAce are expensive, complex and uncommon. The FM-001,
originally designed to monitor a marker of weight loss in healthy people, is a device for measuring
BrAce. The FM-001 is a loading semiconducting gas sensor that is a simple and reusable device. The
aim of this study was to evaluate the correlation between blood total ketone bodies (TKB) and BrAce
measured with the FM-001 in patients with diabetes. Furthermore, through evaluation of that
correlation, we sought to detect patients at high risk of developing diabetic ketoacidosis (DKA).
Thirty-five participants (age 52 [40 –57], T2DM 32, T1DM 3) were enrolled. Scatter plots and linear
regression lines relating BrAce to TKB and the correlation coefficients were calculated.
Receiver-operating characteristic analysis was performed to determine the cut-off for predicting
patients prone to DKA. The results showed that BrAce strongly correlates with TKB ( R = 0.828), and
the correlation was stronger in patients whose serum C-peptide was not low. The optimal BrAce
cut-off for predicting risk of developing DKA was 3400 ppb (AUC 0.924, sensitivity 73.3%,
specificity 100%), which corresponds to a TKB ⩾ 1000 µ mol l −1 . BrAce also weakly correlated with
free fatty acid. Thus, BrAce levels measured with the FM-001 strongly correlate with TKB, even in
patients with diabet...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Shingo Tsunemi, Yuta Nakamura, Kenichi Yokota, Tomoko Nakagawa, Hidekazu Tsukiyama, Yui Kubo, Takeshi Oyanagi, Ayaka Takemoto, Yoshio Nagai, Yasushi Tanaka and Masakatsu Sone Source Type: research