Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR
Objective . With growing recognition of the benefits of preserving residual kidney function (RKF)
and use of incremental treatment regimes, the incentive to measure residual clearance in
haemodialysis patients is increasing. Interdialytic urine collections used to monitor RKF in
research studies are considered impractical in routine care, partly due to the requirement for blood
samples before and after the collection. Plasma solute levels can be estimated if patients are in
'steady state', where urea and creatinine concentrations increase at a constant rate between
dialysis sessions and are reduced by a constant ratio at each session. Validation of the steady
state assumption would allow development of simplified protocols for urine collections in HD
patients. Approach . Equations were derived for estimating plasma urea and creatinine at the start
or end of the interdialytic interval for patients in steady state. Data collected during the BISTRO
study was used to assess the agreement between measured and estimated plasma levels and the effect
of using estimated levels on the calculated glomerular filtration rate (GFR). Main results . The
mean difference between GFR calculated with estimated plasma levels for the HD session after the
collection and a full set of measured levels was 2.0% (95% limits of agreement −10.7% to +14.7%, N
= 316). Where plasma levels for the session before the collection were estimated, the mean
difference was 1.2% (limits of agreem...
Source: Physiological Measurement - Category: Physiology Authors: Elizabeth Lindley, David Keane, John Belcher, Nancy Fernandes Da Silva Jeffcoat, Simon Davies and BISTRO trial investigators Source Type: research