Heritability and risk factors of incident small and large drusen in the Copenhagen Twin Cohort Eye Study: a 20-year follow-up

Introduction: The transition from a normal fundus to one with early drusen ( ≥ 20 small hard drusen) to age-related macular degeneration (AMD) in the form of drusen ≥ 63 µm in diameter is of interest, because small hard drusen may be precursors of large drusen. Study of AMD precursors lesions may provide valuable insight into factors that initiate AMD. Here, the progres sion of drusen was studied over an interval of 20 years in a population-based twin cohort. Methods: Single-center, 20-year follow-up of 138 twins, including biometry, fundus optical coherence tomography, and fundus photography. Macular characteristics were hierarchically classified as (per eye) 1)
Source: Ophthalmologica - Category: Opthalmology Source Type: research