The link between anterior scleral thickness, corneal biomechanical response and ocular parameters

Purpose: to assess anterior scleral thickness (AST) across diverse scleral meridians and to evaluate the relationship with corneal biomechanical response and several ocular parameters.
Methods: This prospective non-randomized study comprised 50 eyes of 50 patients (mean age, 29.02 ± 9.48 years). Anterior scleral thickness was measured meridionally at three scleral locations (1, 2, and 3 mm posterior to the scleral spur) using swept-source optical coherence tomography. A multivariate model was created to associate AST with several ocular parameters. Principal component analy sis (PCA) was used to reduce linearly the dimensionality of seven biomechanical input metrics to two significant components, C1 and C2. Two multivariate analyses were performed to associate C1 and C2 with AST and several ocular parameters.
Results: AST was thickest in the inferior (581 ± 52 µm) an d thinnest in the superior meridian (441 ± 42 µm) when compared to all meridians (p0.05). The sclera exhibited the thinnest point 2 mm posterior to the scleral spur (p

Source: Ophthalmic Research - July 14, 2022 Category: Opthalmology Source Type: research