Acylated sucroses and butenolide analog from the leaves of Tripterygium wilfordii Hook. f. and their potential anti-tyrosinase effects
Fitoterapia. 2022 Jul 4:105250. doi: 10.1016/j.fitote.2022.105250. Online ahead of print.ABSTRACTThree undescribed acylated sucroses (1-3), one undescribed butenolide analog (4) along with three known compounds (5-7) were isolated from the aqueous EtOH extract of the dried leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of spectroscopic analyses, electron circular dichroism (ECD) techniques, and saccharide hydrolysis. All the isolated compounds were tested for their anti-tyrosinase effects. Among them, 6 exhibited similar inhibitory effects on tyrosinase with IC50 values of 0.073 mM comparing to arbutin. Additionally, the possible mechanism of the interaction between 6 and the active site of tyrosinase was explored by molecular docking.PMID:35798062 | DOI:10.1016/j.fitote.2022.105250
Source: Fitoterapia - Category: Biochemistry Authors: Yun-Fei Ai Shu-Hui Dong Bin Lin Xiao-Xiao Huang Shao-Jiang Song Source Type: research
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