Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis

AbstractThe aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in the regeneration of periodontal bone defects in animal models. A systematic review and meta-analysis were conducted following the PRISMA guidelines, and the study was recorded in PROSPERO under reference number CDR42021247462. The PICO question was: is periodontal regeneration (cementum, periodontal ligament and alveolar bone) with MSCs more effective than other techniques? Three groups were considered: Group 1: MSCs alone or mixed with regenerative materials. Group 2: only regenerative materials. Group 3: no regenerative material nor MSCs. The search was conducted using MeSH with a total of 18 articles for qualitative analysis and 5 for quantitative analysis. For the meta-analysis, a modification of the effect size algorithm was developed, which considered a comparison of means between treatments using the Student's t sample distribution. When comparing the effect size between Group 1 and Group 2, the effect size for the new cementum was 2.83  mm with an estimated confidence interval of 95% (CI 95%) between 0.48 and 5.17 mm. When considering the fit to a random-effects model, the combined variance (τ2) was 6.1573  mm, with a standard deviation (SD) of 5.6008 mm and a percentage of total heterogeneityI2 of 92.33% (p <  0.0001). For new bone, the effect size was 0.88 mm, CI 95% − 0.25 to 2.01 mm,τ2 = 1.3108 mm (SD = 1.2021 mm) andI2 = 80.46%,p = 0....
Source: Odontology - Category: Dentistry Source Type: research