The Clinicopathologic Challenge of Nonneoplastic Vulvar Acanthosis

Conclusions There is a group of acanthotic tissue reactions that cannot be classified with standard histopathologic assessment. Further clinicopathologic research into unilateral acanthotic lesions may provide insight into separation of psoriasis and mycosis when organisms are absent. Once nuclear atypia is excluded, immunohistochemistry for p16 and p53 and HPV molecular testing do not assist in diagnostic identification.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Non-HPV Associated Vulvovaginal Disease Source Type: research