Gastrointestinal stromal tumour and other mesenchymal tumours of the gastrointestinal tract: the role of immunohistochemistry in an evolving era of molecular diagnostics

Significant progress has been made in the molecular characterization of soft tissue tumours arising in the gastrointestinal tract, primarily with the identification of recurrent translocations, gene amplifications and mutations in different tumour types. Translational studies have resulted in the development of many diagnostically useful immunohistochemical markers that reflect these underlying genetic changes. In addition, expression of some such markers is associated with distinctive clinical and histologic features, which may impart prognostic or predictive information, particularly for gastrointestinal stromal tumour.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Immunohistochemistry as a surrogate to molecular diagnosis in gastrointestinal pathology Source Type: research