Chemotherapy-Induced Neutropenia and Emerging Agents for Prevention and Treatment: A Review

Cancer treatment with myelosuppressive chemotherapy puts patients at risk of developing chemotherapy-induced neutropenia (CIN). Neutropenia predisposes patients to potentially life-threatening complications, including febrile neutropenia (FN), antibiotic use, hospitalization, and increased mortality.[1] In addition, oncologists may reduce the dose of chemotherapy, which can lead to low relative dose intensity (RDI) and negatively impact treatment outcomes.[2] Granulocyte colony-stimulating factors (G-CSFs), which were first introduced for clinical use in the 1990s, reduced the incidence of these complications and improved patient outcomes.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: General and Supportive Care Source Type: research