A review of DICER1: structure, function and contribution to disease

DICER1 is an important housekeeping gene that encodes a multi-domain enzyme that functions in small RNA processing. The enzymatic products function in several pathways including RNA interference, DNA damage repair and antiviral response. At the protein level, endoribonuclease DICER also plays a role in many human illnesses, and much research is being done to clarify the full spectrum of its functions and relation to neoplastic and non-neoplastic disease. Both somatic and germline mutations in DICER1 have been identified, and germline mutations have been associated with at least two named syndromes: DICER1 syndrome and GLOW syndrome.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Endocrine Pathology: Single-gene Impacts Source Type: research