SARS-CoV-2-specific T cell memory with common TCR αβ motifs is established in unvaccinated children who seroconvert after infection

eTOC SummaryChildren are at lower risk of developing severe COVID-19, yet their primary and memory immune responses are understudied. Rowntree et al. define ex vivo CD8+ and CD4+ T cell responses towards SARS-CoV-2 using peptide-HLA tetramers. They find that children have comparable spike-specific but lower ORF1a- and N-specific memory T cell magnitude with less clonal expansion in comparison to adults.

Source: Immunity - June 7, 2022 Category: Allergy & Immunology Authors: Louise C. Rowntree, Thi H.O. Nguyen, Lukasz Kedzierski, Melanie R. Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F. Allen, E. Bridie Clemens, Brendon Chua, Hayley A. McQuilten, Anastasia A. Minervina, Mikhail V. Pogorelyy, Priyanka Chaurasia, Hyon- Tags: Article Source Type: research