A 5-step root cause analysis model for test overutilization: A study on its application to plasma transferrin testing
CONCLUSIONS: This study presents a 5-step RCA model that offers a customized method to identify the causes of test overutilization. Applying this model to transferrin at our institution revealed 22 leading root causes. Laboratories are encouraged to adopt this RCA model as it can contribute to optimized patient care and more efficient resource allocation.PMID:38447167 | DOI:10.1093/ajcp/aqae015 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 6, 2024 Category: Pathology Authors: Jiracha Jittapranerat Wimol Chinswangwatanakul Source Type: research

Analysis of editor in chief gender and associated journal variables among 126 pathology journals
CONCLUSIONS: Women are significantly underrepresented among editor in chiefs across pathology journals. Journals and affiliated members should advocate for diversity among these influential positions, given their impact on research, science, and medicine.PMID:38437878 | DOI:10.1093/ajcp/aqae018 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 4, 2024 Category: Pathology Authors: Dayle K Wang Landon M Clark Laura D Stephens Brian D Adkins Shazia S Khan Garrett S Booth Jeremy W Jacobs Source Type: research

Analysis of editor in chief gender and associated journal variables among 126 pathology journals
CONCLUSIONS: Women are significantly underrepresented among editor in chiefs across pathology journals. Journals and affiliated members should advocate for diversity among these influential positions, given their impact on research, science, and medicine.PMID:38437878 | DOI:10.1093/ajcp/aqae018 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 4, 2024 Category: Pathology Authors: Dayle K Wang Landon M Clark Laura D Stephens Brian D Adkins Shazia S Khan Garrett S Booth Jeremy W Jacobs Source Type: research

Analysis of editor in chief gender and associated journal variables among 126 pathology journals
CONCLUSIONS: Women are significantly underrepresented among editor in chiefs across pathology journals. Journals and affiliated members should advocate for diversity among these influential positions, given their impact on research, science, and medicine.PMID:38437878 | DOI:10.1093/ajcp/aqae018 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 4, 2024 Category: Pathology Authors: Dayle K Wang Landon M Clark Laura D Stephens Brian D Adkins Shazia S Khan Garrett S Booth Jeremy W Jacobs Source Type: research

Implementation of endometrial cancer molecular subtyping into a hybrid community-academic practice
CONCLUSIONS: Our protocol identified 22 (14%) of 157 LR tumors that harbored incipient intermediate- to high-risk molecular aberrations in TP53, CTNNB1, or L1CAM. Moving forward, results of ongoing trials assessing adjuvant therapy decisions based on molecular classification are necessary to confirm protocol utility and identify appropriate modifications.PMID:38430556 | DOI:10.1093/ajcp/aqae010 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 2, 2024 Category: Pathology Authors: Elizabeth O Ferreira Alexandra M Schefter Abby Brustad Molly E Klein Mahmoud A Khalifa Boris Winterhoff Andrew C Nelson Source Type: research

Implementation of endometrial cancer molecular subtyping into a hybrid community-academic practice
CONCLUSIONS: Our protocol identified 22 (14%) of 157 LR tumors that harbored incipient intermediate- to high-risk molecular aberrations in TP53, CTNNB1, or L1CAM. Moving forward, results of ongoing trials assessing adjuvant therapy decisions based on molecular classification are necessary to confirm protocol utility and identify appropriate modifications.PMID:38430556 | DOI:10.1093/ajcp/aqae010 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 2, 2024 Category: Pathology Authors: Elizabeth O Ferreira Alexandra M Schefter Abby Brustad Molly E Klein Mahmoud A Khalifa Boris Winterhoff Andrew C Nelson Source Type: research

Radical prostatectomy cancer grade and percentage of Gleason pattern 4 estimated by global vs individual tumor grading correlate differently with the risk of biochemical recurrence in Grade Group 2 and 3 cancers
CONCLUSIONS: Grade Group, GP4%, and margin status derived by global vs individual tumor grading predict postoperative biochemical recurrence statistically significantly differently. This difference has important implications if results derived from cohorts graded using different methods are compared.PMID:38412318 | DOI:10.1093/ajcp/aqae003 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Oleksandr N Kryvenko Jonathan I Epstein Ali Merhe Oleksii A Iakymenko Ricardo De Almeida E Silva Dimple Kumar Chanamolu Laurence M Briski Deukwoo Kwon Ivan Nemov Sanoj Punnen Alan Pollack Radka Stoyanova Dipen J Parekh Merce Jorda Mark L Gonzalgo Source Type: research

Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research

Radical prostatectomy cancer grade and percentage of Gleason pattern 4 estimated by global vs individual tumor grading correlate differently with the risk of biochemical recurrence in Grade Group 2 and 3 cancers
CONCLUSIONS: Grade Group, GP4%, and margin status derived by global vs individual tumor grading predict postoperative biochemical recurrence statistically significantly differently. This difference has important implications if results derived from cohorts graded using different methods are compared.PMID:38412318 | DOI:10.1093/ajcp/aqae003 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Oleksandr N Kryvenko Jonathan I Epstein Ali Merhe Oleksii A Iakymenko Ricardo De Almeida E Silva Dimple Kumar Chanamolu Laurence M Briski Deukwoo Kwon Ivan Nemov Sanoj Punnen Alan Pollack Radka Stoyanova Dipen J Parekh Merce Jorda Mark L Gonzalgo Source Type: research

Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research

Radical prostatectomy cancer grade and percentage of Gleason pattern 4 estimated by global vs individual tumor grading correlate differently with the risk of biochemical recurrence in Grade Group 2 and 3 cancers
CONCLUSIONS: Grade Group, GP4%, and margin status derived by global vs individual tumor grading predict postoperative biochemical recurrence statistically significantly differently. This difference has important implications if results derived from cohorts graded using different methods are compared.PMID:38412318 | DOI:10.1093/ajcp/aqae003 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Oleksandr N Kryvenko Jonathan I Epstein Ali Merhe Oleksii A Iakymenko Ricardo De Almeida E Silva Dimple Kumar Chanamolu Laurence M Briski Deukwoo Kwon Ivan Nemov Sanoj Punnen Alan Pollack Radka Stoyanova Dipen J Parekh Merce Jorda Mark L Gonzalgo Source Type: research

Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research

Radical prostatectomy cancer grade and percentage of Gleason pattern 4 estimated by global vs individual tumor grading correlate differently with the risk of biochemical recurrence in Grade Group 2 and 3 cancers
CONCLUSIONS: Grade Group, GP4%, and margin status derived by global vs individual tumor grading predict postoperative biochemical recurrence statistically significantly differently. This difference has important implications if results derived from cohorts graded using different methods are compared.PMID:38412318 | DOI:10.1093/ajcp/aqae003 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Oleksandr N Kryvenko Jonathan I Epstein Ali Merhe Oleksii A Iakymenko Ricardo De Almeida E Silva Dimple Kumar Chanamolu Laurence M Briski Deukwoo Kwon Ivan Nemov Sanoj Punnen Alan Pollack Radka Stoyanova Dipen J Parekh Merce Jorda Mark L Gonzalgo Source Type: research

Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research

A longitudinal mixed-methods study of pathology explanation clinics in patients with newly diagnosed localized prostate cancer
CONCLUSIONS: In this small pilot, PECs positively affected patients with prostate cancer, their clinicians, and the overall care system. Additional studies in larger populations and diverse settings will be useful.PMID:38387034 | DOI:10.1093/ajcp/aqae008 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 22, 2024 Category: Pathology Authors: Sarah E Bergholtz Sophia R Kurnot Esha Elahi Melissa DeJonckheere Sarah T Hawley Scott R Owens Simpa Salami Todd M Morgan Cathryn J Lapedis Source Type: research