Predictors of outcome in patients with moderate mixed aortic valve disease
Conclusions
Patients with truly moderate MAVD have a high incidence of death and heart failure hospitalisation (43% at 3.5 (2.5–4.7) years). Within this group, a high-risk group characterised by disproportionately low aortic Vmax (≤2.8 m/s) and adverse remodelling (LVEF ≤50%) have the worst outcomes. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Patel, K. P., McKenna, M., Thornton, G. D., Vandermolen, S., Abdulelah, Z. A., Awad, W., Baumbach, A., Mathur, A., Treibel, T. A., Lloyd, G., Mullen, M. J., Bhattacharyya, S. Tags: Valvular heart disease Source Type: research
Efficacy and safety of colchicine for the treatment of myopericarditis
Conclusion
In patients with first attack of pericarditis associated with myocardial involvement, colchicine was safe and efficacious for the reduction of recurrences. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Collini, V., De Martino, M., Andreis, A., De Biasio, M., Gaspard, F., Paneva, E., Tomat, M., Deferrari, G. M., Isola, M., Imazio, M. Tags: Open access, Editor's choice Special populations Source Type: research
Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors
Conclusion
A clinical prediction model with ECG data (left bundle branch block, left atrial enlargement, left heart axis, Cornell’s criteria for left ventricular hypertrophy and heart rate) may aid in ruling out LVEF <45%. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: de Baat, E. C., Merkx, R., Leerink, J. M., Boerhout, C., van der Pal, H. J. H., van Dalen, E. C., Loonen, J., Bresters, D., van Dulmen-den Broeder, E., van der Heiden-van der Loo, M., van den Heuvel, M. M., Kok, J. L., Louwerens, M., Neggers, S. J. C. M. Tags: Open access Heart failure and cardiomyopathies Source Type: research
Percutaneous coronary intervention versus medical therapy in stable angina: a matched cohort study
Conclusions
PCI plus OMT was associated with higher rate of primary endpoint of MI, stroke, cardiac death as compared with OMT alone in patients with pure stable angina at 9.3-year follow-up in large population. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Jo, S.-H., Kim, H., Kim, H.-J., Lee, M.-H., Seo, W.-W., Kim, M., Kim, H.-L. Tags: Coronary artery disease Source Type: research
Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study
Conclusions
Genetic liability to HDPs is associated with higher CVD risk, lower blood pressure levels and earlier hypertension diagnosis. Our study suggests similar findings in ever pregnant women, nulligravidae and men, implying biological mechanisms relating to HDPs are causally related to CVD risk. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Tschiderer, L., van der Schouw, Y. T., Burgess, S., Bloemenkamp, K. W. M., Seekircher, L., Willeit, P., Onland-Moret, C., Peters, S. A. E. Tags: Open access Cardiac risk factors and prevention Source Type: research
Heightened long-term cardiovascular risks after exacerbation of chronic obstructive pulmonary disease
Conclusion
Moderate and severe COPD exacerbations are independent risk factors for adverse CV events, especially HF decompensation. The impact of optimising COPD management on CV outcomes should be evaluated. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Hawkins, N. M., Nordon, C., Rhodes, K., Talukdar, M., McMullen, S., Ekwaru, P., Pham, T., Randhawa, A. K., Sin, D. D. Tags: Open access Cardiac risk factors and prevention Source Type: research
Birth cohort effects on diagnosed atrial fibrillation incidence: nationwide cohort study from 1980 to 2018
Conclusion
Substantial birth cohort effects, independent of age and calendar period, influence trends in diagnosed AF incidence. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Vinter, N., Cordsen, P., Johnsen, S. P., Benjamin, E. J., Frost, L., Trinquart, L. Tags: Arrhythmias and sudden death Source Type: research
Exercise intolerance in a man with ischaemic cardiomyopathy and biventricular pacing
Clinical introduction A patient in his 60s with a history of ischaemic cardiomyopathy and severely reduced left ventricular ejection fraction of 20% presents with worsening dyspnoea on exertion. He is tolerating therapeutic doses of guideline-directed medical therapy including sacubitril-valsartan, carvedilol, spironolactone and empagliflozin, and has a biventricular implantable cardiac defibrillator. He undergoes cardiopulmonary exercise testing (CPET) using the treadmill-modified Bruce protocol and is found to have a severely reduced peak oxygen consumption (VO2) (14.9 mL/kg/min) despite maximal effort. The test was stop...
Source: Heart - April 25, 2024 Category: Cardiology Authors: Bevan, G. H., Buber, J. Tags: Arrhythmias and sudden death Source Type: research
Eosinophilic myocarditis: systematic review
Conclusion
EMB is the mainstay for diagnostic testing for EM. CMR is potentially helpful for screening in appropriate clinical scenarios. Regarding treatment, there is no consensus regarding the optimal dosage of corticosteroids. Large clinical trials are warranted to further explore the utility of CMR in the diagnosis of EM and steroid regimen in treating EM. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Techasatian, W., Gozun, M., Vo, K., Yokoyama, J., Nagamine, T., Shah, P., Vu, K., Zhang, J., Nishimura, Y. Tags: Systematic review Source Type: research
Birth cohort effect in atrial fibrillation: a matter of detection?
Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder, affecting an estimated 43 million people globally.1 In the last 20 years, the incidence of AF increased by 33% and it is expected to increase by threefold in the next three decades.1 Long-term AF management, including outpatient visits, hospitalisations and disabilities from stroke and heart failure (HF), adds substantial burden on healthcare resources and costs, accounting for 2.6% of the total annual healthcare expenditure of European countries.2 As a result, AF has emerged as a major public health concern and a potential future epidemic.1 The...
Source: Heart - April 25, 2024 Category: Cardiology Authors: Samuel, M., Rienstra, M. Tags: Editorials Source Type: research
Assessment and management of asymptomatic atrial fibrillation
Atrial fibrillation (AF) is the most common sustained cardiac dysrhythmia encountered in practice. It is currently estimated that AF affects approximately 2% of the general population; however, the true prevalence of AF is likely to be at least 3%–4% when asymptomatic AF is considered. For clinically apparent AF, the investigations and management are relatively well established. The identification of minimally symptomatic patients is challenging, and furthermore, the optimal management is less certain. Although there is some debate about the ideal treatment pathway for asymptomatic AF, in most cases, the investigatio...
Source: Heart - April 15, 2024 Category: Cardiology Authors: Andrade, J. G., Deyell, M. W., Bennett, R., Macle, L. Tags: Education in Heart Source Type: research
Filamin A heart valve disease as a genetic cause of inherited bicuspid and tricuspid aortic valve disease
Conclusion
The patients with FLNA variants present frequent aortic valve disease and worse outcomes. Bicuspid aortic valve is more frequent in patients carrying the FLNA-MVD variants. These unique features should be factored into the management of patients with dystrophic and/or bicuspid aortic valve. (Source: Heart)
Source: Heart - April 15, 2024 Category: Cardiology Authors: Delwarde, C., Toquet, C., Boureau, A. S., Le Ruz, R., Le Scouarnec, S., Merot, J., Kyndt, F., Bernstein, D., Bernstein, J. A., Aalberts, J. J. J., Le Marec, H., Schott, J.-J., Roussel, J.-C., Le Tourneau, T., Capoulade, R. Tags: Valvular heart disease Source Type: research
Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis
Conclusions
CT-derived aortic valve perivascular adipose tissue attenuation is not associated with AS disease severity, activity or progression suggesting that it has no value in the investigation and management of patients with AS. (Source: Heart)
Source: Heart - April 15, 2024 Category: Cardiology Authors: Botezatu, S. B., Yu, X., Meah, M. N., Williams, M. C., Dey, D., Newby, D. E., Tzolos, E., Dweck, M. R. Tags: Valvular heart disease Source Type: research
Young man with chest pain and an abnormal echocardiogram
Clinical introduction A man in his 40s with a history of hyperlipidaemia presented with intermittent, dull left-sided chest pain for 2 weeks that was not consistently exertional. He denied dyspnoea, cough, fevers, recent travel or exposure to sick people. He did not smoke or use alcohol or illicit drugs. There was no pertinent family history. Physical examination, an ECG, basic laboratories and a chest X-ray were unremarkable. The patient was referred for an exercise nuclear study and did 11 min on the Bruce protocol without angina or ischaemic ECG changes. Myocardial scintigraphic perfusion images at stress and rest were ...
Source: Heart - April 15, 2024 Category: Cardiology Authors: Peters, M., Kalra, D. Tags: Image challenges Source Type: research
Cardiovascular sequelae of trastuzumab and anthracycline in long-term survivors of breast cancer
Conclusions
The presence of asymptomatic LVSD, abnormal cardiac biomarkers and cardiac risk factors in participants treated with trastuzumab and anthracycline at least 5 years previously is common, even in those with normal LVEF on completion of treatment. Our findings reinforce the relevance of comprehensive evaluation of cardiovascular risk factors following completion of cancer therapy, in addition to LVEF assessment. (Source: Heart)
Source: Heart - April 15, 2024 Category: Cardiology Authors: Glen, C., Morrow, A., Roditi, G., Hopkins, T., Macpherson, I., Stewart, P., Petrie, M. C., Berry, C., Epstein, F., Lang, N. N., Mangion, K. Tags: Open access Special populations Source Type: research
