Predictors and outcomes of pacemaker implantation in patients with cardiac amyloidosis
Conclusions
Conduction system disease requiring PPM is a common complication in CA that affects up to 20.6% of patients. QRS duration and IVS thickness are independently associated with PPM implantation. A PPM implantation at 12 months model was devised and validated to identify patients with CA at higher risk of requiring a PPM and who require closer follow-up. (Source: Heart)
Source: Heart - December 15, 2023 Category: Cardiology Authors: Saturi, G., De Frutos, F., Sguazzotti, M., Gonzalez-Lopez, E., Nardi, E., Dominguez, F., Ponziani, A., Cabrera, E., Caponetti, A. G., Lozano, S., Massa, P., Cobo-Marcos, M., Accietto, A., Castro-Urda, V., Giovannetti, A., Toquero, J., Gagliardi, C., Gomez Tags: Editor's choice Heart failure and cardiomyopathies Source Type: research
Clinical features and response at head-up tilt test of patients with situational syncope
Conclusions
Compared with VVS, patients with SS have different clinical characteristics and a higher prevalence of hypotensive drugs leading to hypotensive susceptibility. The positivity rate of HUTT is high and similar to that of VVS, although patients with SS show a higher prevalence of hypotensive responses. (Source: Heart)
Source: Heart - December 15, 2023 Category: Cardiology Authors: Russo, V., Parente, E., Comune, A., Laezza, N., Rago, A., Nigro, G., Brignole, M. Tags: Arrhythmias and sudden death Source Type: research
Updated definition of pulmonary hypertension and outcome after transcatheter aortic valve implantation
Conclusions
New ESC PH cut-offs increased the number of PH diagnoses. The presence of PH, particularly in the setting of increased PVR, identify patients at higher risk for postprocedural mortality and rehospitalisation. Normalisation of PH was associated with better survival only in I-PoC group. (Source: Heart)
Source: Heart - December 15, 2023 Category: Cardiology Authors: Cardaioli, F., Nai Fovino, L., Fabris, T., Masiero, G., Arturi, F., Trevisanello, A., Zuccarelli, V., Napodano, M., Fraccaro, C., Continisio, S., Tarantini, G. Tags: Aortic and vascular disease Source Type: research
Disease-specific therapy for the treatment of the cardiovascular manifestations of Fabry disease: a systematic review
Conclusion
It remains unclear whether disease-specific therapy sufficiently impacts the cardiovascular manifestations of Fabry disease. Further work, ideally in larger cohorts, with more standardised clinical and phenotypic outcomes, the latter measured using contemporary techniques, are required to fully elucidate the cardiovascular impact of disease-specific therapy.
PROSPERO registration number
CRD42022295989. (Source: Heart)
Source: Heart - December 15, 2023 Category: Cardiology Authors: Orsborne, C., Black, N., Naish, J. H., Woolfson, P., Reid, A. B., Schmitt, M., Jovanovic, A., Miller, C. A. Tags: Open access Systematic review Source Type: research
Case of presyncope with mitral regurgitation
Clinical introduction A woman in her 70s presented with mild dyspnoea on exertion with occasional presyncope. Her pulse was 38 beats/min and regular. There was no cardiomegaly. On auscultation, she was found to have a probable late diastolic or presystolic murmur of variable duration. She also had a pan-systolic grade 2/6 murmur at the apex. Continuous wave Doppler imaging at the mitral valve has been provided in figure 1. Figure 1Continuous wave Doppler imaging at the mitral valve. Question What is the likely aetiology and the cause of late diastolic murmur? Complete heart block (CHB) with diastolic mitral regurgitation ...
Source: Heart - December 15, 2023 Category: Cardiology Authors: Mondal, S., Kumar, S. S., Kesavan, V. Tags: Image challenges Source Type: research
Regional variations in heart failure: a global perspective
Heart failure (HF) is a global public health concern that affects millions of people worldwide. While there have been significant therapeutic advancements in HF over the last few decades, there remain major disparities in risk factors, treatment patterns and outcomes across race, ethnicity, socioeconomic status, country and region. Recent research has provided insight into many of these disparities, but there remain large gaps in our understanding of worldwide variations in HF care. Although the majority of the global population resides across Asia, Africa and South America, these regions remain poorly represented in epide...
Source: Heart - December 15, 2023 Category: Cardiology Authors: Yogeswaran, V., Hidano, D., Diaz, A. E., Van Spall, H. G. C., Mamas, M. A., Roth, G. A., Cheng, R. K. Tags: Review articles Reviews Source Type: research
Cochrane corner: centre versus telemedicine approaches to cardiac rehabilitation
Introduction Centre-based cardiac rehabilitation (CBCR) is typically offered to individuals post cardiac event or diagnosis to support recovery and reduce risk of future cardiovascular events. Despite strong recommendations for referral of individuals with coronary heart disease (CHD) and heart failure (HF) to cardiac rehabilitation (CR) programmes in clinical guidelines, global access remains limited, and participation remains poor. Home-based CR (HBCR) programmes, including those supported by technology and facilitated by healthcare professionals, are increasingly being used as alternative modes to CBCR in an attempt to ...
Source: Heart - December 15, 2023 Category: Cardiology Authors: McDonagh, S. T. J., Dalal, H., Moore, S., Clark, C. E., Taylor, R. S. Tags: Cochrane Corner Source Type: research
Prognostic implications of pulmonary vascular resistance in transcatheter aortic valve implantation
Pulmonary hypertension (PH) is a complex and progressive disorder characterised by elevated pulmonary artery pressure. It is a serious condition that can significantly impair quality of life and lead to fatal cardiovascular complications if left unmanaged. Transcatheter aortic valve implantation (TAVI) is a minimally invasive surgical procedure that has revolutionised the treatment of severe aortic stenosis (AS). However, the presence of PH in patients undergoing TAVI has been identified as a critical factor that can influence clinical outcomes, both in the short and long terms. In 2022, the most recent update of the Europ...
Source: Heart - December 15, 2023 Category: Cardiology Authors: Kusunose, K., Ikemiyagi, H. Tags: Editorials Source Type: research
Situational vs vasovagal syncope: one but different?
Reflex syncope is defined as a transient loss of consciousness due to a neurally mediated reflex causing sudden-onset vasodilation and bradycardia, leading to a steep decrease in blood pressure and cerebral hypoperfusion.1 According to the current European Society of Cardiology syncope guidelines, reflex syncope can be broadly classified into four groups: vasovagal syncope (VVS), situational syncope, carotid sinus syndrome and non-classical forms of syncope.1 Individuals with VVS and situational syncope are generally regarded to be at low risk of serious adverse outcomes, such as premature death, cardiac arrhythmias, pacem...
Source: Heart - December 15, 2023 Category: Cardiology Authors: Johansson, M., Fedorowski, A. Tags: Editorials Source Type: research
For Heart: the journey at the forefront of cardiovascular medicine continues
As I step into the role of Editor-in-Chief for Heart, I am both excited and honoured to lead one of the world’s most esteemed cardiovascular journals. My gratitude goes out to BMJ Publishing Group and the British Cardiovascular Society (BCS) for entrusting me with this great responsibility. I would also like to thank my predecessor, Professor Catherine Otto, and her team, who brought numerous innovations to elevate the journal’s value over the past 10 years. Building on her legacy, my goal over the coming years is to increase the impact of the journal further. Our mission at Heart is to advance scholarship in t...
Source: Heart - December 15, 2023 Category: Cardiology Authors: Rahimi, K. Tags: Editorials Source Type: research
Sleep-disordered breathing and cardiovascular disease: who and why to test and how to intervene?
Sleep-disordered breathing (SDB) is common in individuals with established cardiovascular disease (CVD), particularly those with heart failure (HF). There are two main types of SDB, central sleep apnoea (CSA) and obstructive sleep apnoea (OSA) which frequently overlap as mixed SDB. Investigating for SDB could be considered in patients with excessive daytime sleepiness, male sex, high body mass index, low ejection fraction, atrial fibrillation (AF), in patients with no dipping blood pressure pattern, recurrent paroxysms of nocturnal dyspnoea or when an apnoea is witnessed. Excessive daytime sleepiness is less likely to be r...
Source: Heart - November 27, 2023 Category: Cardiology Authors: Vazir, A., Kapelios, C. J. Tags: Education in Heart Source Type: research
Exploring the mechanisms responsible for reduced systolic function in high-gradient aortic stenosis
Conclusion
The pathophysiological problem in patients with high-gradient AS with rEF relates to an excessively increased afterload due to more severe valvular stenosis, with preserved intrinsic contractile function. Myocardial fibrosis in the rEF group did not translate into worse muscle function. (Source: Heart)
Source: Heart - November 27, 2023 Category: Cardiology Authors: Liebenberg, J., Doubell, A., Steyn, J., Herbst, P. Tags: Valvular heart disease Source Type: research
Non-COVID-19 cardiovascular pathology from return-to-play screening in college athletes after COVID-19
Conclusion
Major non-COVID-19 cardiovascular pathology was identified in 1/500 college athletes undergoing return-to-play screening. In athletes without ECG abnormalities, TTE’s added value was limited to pathological aortic root dilatation in 1/1000 athletes and minor abnormalities warranting surveillance in 1/160 athletes. Two-thirds of findings were incidental or of uncertain significance. (Source: Heart)
Source: Heart - November 27, 2023 Category: Cardiology Authors: Klein, C. F., Petek, B. J., Moulson, N., Baggish, A. L., Churchill, T. W., Harmon, K. G., Kliethermes, S. A., Patel, M. R., Drezner, J. A. Tags: COVID-19 Special populations Source Type: research
Restoration of right ventricular function in the treatment of pulmonary arterial hypertension
Conclusion
After treatment initiation, 60% of patients with PAH reach or maintain the 45% RVEF threshold, which is associated with a long-term stable RV function and favourable prognosis. (Source: Heart)
Source: Heart - November 27, 2023 Category: Cardiology Authors: Celant, L. R., Wessels, J. N., Kianzad, A., Marcus, J. T., Meijboom, L. J., Bogaard, H. J., de Man, F. S., Vonk Noordegraaf, A. Tags: Open access Pulmonary vascular disease Source Type: research
Prediction of worsening heart failure in hypertrophic cardiomyopathy using plasma proteomics
Conclusions
The present study with comprehensive plasma proteomics profiling demonstrated a high accuracy to predict worsening HF in patients with HCM and identified the Ras-MAPK and related signalling pathways as potential underlying mechanisms. (Source: Heart)
Source: Heart - November 27, 2023 Category: Cardiology Authors: Lumish, H. S., Liang, L. W., Hasegawa, K., Maurer, M. S., Fifer, M. A., Reilly, M. P., Shimada, Y. J. Tags: Editor's choice Heart failure and cardiomyopathies Source Type: research
